Comment on “Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression”

Taniguchi et al . (Research Articles, 17 July 2020, p. 269) claim that the cytokine interleukin-33 induces accumulation of tumor-associated macrophages expressing immunoglobulin E receptor FcεRI. Although these findings hold great therapeutic promise, we provide evidence anti-FcεRI antibody used in this study is not specific for FcεRI on macrophages, which raises concerns about validity some conclusions.